Genetic Engineering

Scientists cross breed them. Most commonly used are genetic fruit flies to study the effects of genetic changes on development. Flies are preferred over other other animals because their vertebrae are simpler than other organisms. Modified bacteria are used to produce the protein insulin, to treat genetic diseases like diabetes, hemophilia, and dwarfism. Transgenic animals have had their genes altered. A majority of these animals are mice. Scientists can now produce these animals thanks to Crick and Watson discoveries. A transgenic plant; however, has genes that have en inserted in them rather than through pollination.Benefits of these plants are that they can fight droughts, as well as insect resistance. Less pesticide would be used. An example of a transgenic plant is the rape plant, which pollinates weeds. According to Google. Com, DNA fingerprinting is the analysis from samples of body tissues or fluids in order to identify individuals. It is very unlikely two people would have t he same fingerprint. DNA fingerprinting is beneficial in many ways including paternity tests, crime investigation and identify organisms causing a diseases.The testing can be done voluntarily by providing a sample of blood or a swab of the cheeks inside a person's mouth . The Human Genome Project was completed in April 2013 and it was a computerized system where you donate your DNA to be scanned into a computer base worldwide. They match your DNA with people all over the world. You paid to have your DNA sent in and all our genes sent together are known as a ‘genome. ‘ The project is beneficial because they can track diseases and help prevent them. Gene therapy is a technique that helps prevent or treat disease by using genes.Gene therapy is not unethical, it could prevent diseases from passing down through generations. I feel this way because it could help cure diseases that we never had the privilege to cure before. If I were to create my own transgenic organism it woul d be a mix between contractible that captures light from the sun and a cow. Transgenic cow, can provide food and sunlight received from the bacteria. It does not take up farmland all it has to do is stand in the sun. It can get all the protein and nutrients needed. Cows give us milk and meat, which could be healthier without all the pesticides. I would all the animal cannon. Genetic Engineering Genetic Engineering – A Curse or a Blessing? What is geneitc engineering? Many struggle to understand the real meaning and outcrops of this complicated, highly expensinve procedure. Genetic Engineering is a direct human manipulation of an organism’s DNA structure. As intricated as it seems, it’s a technology that has been used for decades, and is soon to outbreak into a real â€Å"Cloning Aeon†. Therefore, how could we know the benefits and the drawbacks of this technique?Let us take a hinge at the striking, egregious discoveries this subject has brought to the world: from SciFi novels to the first synthetic life forms, from genetical engineered wheat to dreaful mutations of the human bodies. Indeed, it seems as if we are already living the much-dreamt-of blazing, scientific inventions. Still, if so many types of drugs and cures have been made-up from just a few mutations, one may wonder how come the biggest issues regarding human incurable illnesses have not been resolved yet.No one can deny this: we own a technology way beyond our understanding, we hold a highly destructive power in our rubber science lab gloves, yet we feel listless when facing the most questionable allegation: Where are the cures for Cancer, AIDS and Alzheimer, diseases that break our world apart? Isn’t it curious how scientist try to create artificial lives instead of curing the genuine ones? We should admit that it’s not to be our â€Å"contemporany age† anymore. It’s a dawn of biohackers. Biohacking comes along with interests.Interests come along with strifes. And strifes inevitably lead to casualties. By the same token, millions of people could be left to struggle in an obscure, isolated self-made world in which they think they could be saved. It’s a tryout, it’s a new selection that many conspiracies theories affirm. Although we should not forget the cloned Dolly sheep and the rest of the pioneers in this area, I dar e say that genetic engineering has not yet proved to be something more than a handicap to what human society might mean.

Disability in Sports

Sports for persons with disabilities are described using the disability element and not using the sporting/athlete element as is usually common in traditional sports. For example, in a sporting activity like volleyball there may be more than one team for the same gender and age category due to the different divisions created to cater for the varied degrees of disabilities. Even so, this does not mean that sports for persons with disabilities are inferior to those practiced by their counterparts without disabilities.In fact, the core tasks of organization, management, officiating, competing, and development of the sports for persons with disability are more or less similar to those carried out in their colleagues without disabilities. They are all run by international bodies that do similar tasks of identifying, nurturing, funding, and developing talent just as in the case with traditional sports. For example, the management of the game of Tennis for persons with disabilities sport is carried out by the International Tennis Federation.Persons with disabilities are accorded equal opportunities to compete at the international level during major global sporting meetings. For instance, the â€Å"Paralympics Game, Special Olympics World Games, and the Deaflympics Games† (p. 136) are the three major global sporting events that brings together competitors from all parts of the world. Again, sports for persons with disabilities are organized into summer and winter to allow for proper preparation as well as not to coincide with other global events.Basically, the underlying idea on sports for persons with disabilities, particularly the global tournaments is to explore the various abilities and reward them. The Paralympics Games are generally meant for professional athletes with one or multiple disabilities to compete. Disabilities here can be taken to include cerebral palsy, amputation, visual impairment, and dwarfs among other types of disabilities. On the other h and, Special Olympics form a relatively smaller outing for persons with disabilities.This event covers a wide range of disabilities that touches on cognitive and developmental with the main aim being not to compete for winning wards but to just to take part in the event. Generally, the rules applied here are more or less similar to those applied in traditional sports with minor modifications made to cater for specific disabilities. Deaflympics Games are more or less similar to the Paralympics only that they specifically deal with Deaf athletes.Perhaps another very important aspect of disability sports is the coaching part of it. Given their physically challenged nature, persons with disability may find it very hard committing themselves to sports. In this regard coaches working with persons with disabilities should be highly qualified and most importantly motivated individuals capable of providing both sport-specific training as well as psychological mindset to the athletes.Unfortun ately, this is not always the case with many athletes – some do not have access to coaching facilities while others access ill-prepared coaches who end up not helping them. Essentially, coaches should be professionally trained people, probably retired disability sports athletes who can understand and diagnose varied remedies for disability sports athletes. Ideally, they should be very listening so as to notice any change in attitudes among their trainees and make the necessary adjustments in training.They should also liaise with the necessary medical practitioners to have the disabilities checked to avoid cases of strain or even under training. Most importantly, they should complement disability sports-specific training styles with other traditional coaching methods such as use of video tapes for comparative purposes. Due to the bulging number of athletes with disabilities venturing into sports, there has been notable increase in demand for disability sports medicine and trea tment.Essentially, the overall fitness of athletes with disabilities is greatly determined by the nature of training they undertake as well as the medicine or treatment they undergo. Moreover, some of the disabilities demands require careful medical checkups to diagnose any potential health lapses, to prevent future infection and injury, as well as to give overall body care. Such medication should be closely linked to normal training particularly to the affected body parts.Athletes with disabilities require a great deal of equipments to perform to their optimum. Apart from the normal sports equipments utilized in traditional sports, disability sports require complex and expensive activity-specific equipments without which the activity cannot take place. Amputees taking part in wheelchair basketball may be hindered greatly due to the poor nature of their wheelchairs. Perhaps, this is one of the few areas that bring out the huge difference between traditional and disability sports.Wit h the proliferation of technological innovations, disability sports has been greatly enhanced as new, reliable, and efficient activity-specific equipments are now available. Organizing disability sports involves more or less the usual procedures involved in traditional sport. Basically, the tenets of event management are employed in making disability sports events a success. The whole process is done under the stewardship of the democratically elected management boards, depending on the type of sport being held as well as whether the event is being held at a national or even international level.It involves the forming of planning and organizing committees that are charged with the responsibilities of focusing on critical issues such as booking and preparation of fields to suit the various disability sports activities. Again, the committees’ makes accommodation and transport arrangements, preparation of sport facilities such as fields, courts etc, and coordinates security team s particularly in this era of global terrorism, and works closely with the media people.

Book Store Business Essay Example | Topics and Well Written Essays - 750 words

Book Store Business - Essay Example An extension of the used book store without seating for espresso kiosk and snack bar is not an ideal decision because it reduces the appeal of the store. In case the expansion is planned with a large scale renovation to the store with a lengthier menu to chose, additional furniture, shelves and interior design, expansion costs may range from $40000 to $80000. Returns from the investment for expansion are lucrative since coffee kiosks that sell specialty coffee is a profitable business. Material cost for the preparation is lower than twenty five percent of the sale price (Plan A: The small, bookstore-owned coffee bar 2002). The used book store is located in a shopping mall and stocks book in various categories. They include mathematics, arts and entertainment, children’s fiction, antiques and collectibles, humor, history, law, literary criticism, biography and autobiography, children’s non-fiction, cooking education, games, house and home, language arts and disciplines, body, mind and spirit, computers, gardening, family relationship’s, business and economics, current affairs, health and fitness, foreign language study, medical books, self help, sports and recreation, nature, poetry, pets, religion, philosophy, technology, philosophy, study aids, true stories, reference, travel and science (Browse Book Categories 2008). Online sales of used books have reached a growth rate of thirty percent in the recent past. This is due to the vast customer base available online and the comparative lesser cost in reaching these customers around the world. The store specialized in used study books for which the market share is huge. Specialized advertising in student related websites and educational websites frequented by students serves as the main mode of sales promotion. There is a high demand for used books for various reasons. The used books may be required because it is out of print and students require it in class, or the book may not

International Business Law Essay Example | Topics and Well Written Essays - 1500 words

International Business Law - Essay Example Over the last decade, the caseload of the ICSID notably increased mainly as a result of an increase in foreign investment practices. Among the 263 registered cases at ICSID as on 30th March 2007, the Argentine government involved in more than 30 cases as an effect of Argentina’s economic crisis (â€Å"Orinton Lawfirm†). ICSID provisions for Boris From the given case context, it is clear that Nonatian government does not give much emphasis on the protection of investor interests. However, Nonatia and Russia (home country of Boris) are signatories to the ICSID. Hence, Boris will be protected by the ICSID provisions even though the Nonatian government does not try to safeguard his financial interests. The ICSID mainly provides conciliation and arbitration facilities to contracting states and nationals of other contracting states in order to resolve investment disputes. Conciliation According to ICSID provisions, Boris may submit a request in writing to the Secretary-Genera l to institute conciliation proceedings if he is not satisfied with the dealing of Nonatian government in future. While requesting for conciliation, Boris has to clearly address detailed information concerning the dispute. The Secretary-General (as cited in Davidson Ciambella) will register the request unless he finds the dispute is outside the jurisdiction of the Center (331-332). As per the provision of Article 29, a Conciliation Commission is constituted immediately after the registration of the conciliation request. The Commission may contain a conciliator or sometimes any uneven numbers of conciliators according to the mutual agreement of both the parties. During the course of conciliation proceedings, the Commission clarifies the causes of disputes between parties with intent to suggest mutually acceptable solutions immediately. At various phases of the proceedings (as cited in Rayfuse,), the Commission may recommend terms of settlement to the parties (ICSID Reports). Under th is practice, both the parties will cooperate in good faith with intent to assist the Commission to carry out its functions smoothly and flawlessly (â€Å"Australian government†). Hence, Boris can ensure maximum cooperation of the Nonatian government on the strength of ICSID provisions because both of them (Nonatian government and Boris) need to give most serious considerations to the Commission’s recommendations. The effective intervention of the ICSID would probably force the Nonatian government to focus more on the needs of Boris; and in fact, this situation assists Boris to take maximum advantages of his investment in Nonatia. It would be an effective method for Boris on the ground of cost and time as it involves simple legal proceedings. However, it seems that conciliation proceedings of ICSID are not much effective for resolving complex disputes, and hence it is recommendable for Boris to seek the help of other ICSID provisions if the issue has multifarious effect s. Arbitration The submission of arbitration request is similar to that of request for conciliation. Once the arbitration request is registered by the General-Secretary, an Arbitration Council is constituted as early as possible. The Arbitration Council consists of arbitrator(s) whereas conciliator(s) represents Conciliation Comm

Comparision of Retirement Plans for employees working in the private Essay

Comparision of Retirement Plans for employees working in the private sector vs employees working in the public sector - Essay Example The similarities and differences in the retirement benefit plans, including taxation of pension as well as the profit sharing plans, between the private and the public sector are critically analyzed and explored in detail. According to Gucciardi (2009), the pension plans of the public sector workers are stable and offer the workers certainty during their retirement period. The public sector recently made changes in its plan to improve the benefits the personnel receive. The public sector employers are responsible for almost all the contributions made to the pension system on behalf of their employees. Generally, the public sector workers are responsible for less than one percent of the contribution costs with their employers responsible for in excess of 99 % (Gucciardi, 2009). The private sector pension plan is different from the public one in that it is mainly based on defined contributions, unlike the defined benefit employed by public sector. Majority of private sector employers provide their personnel with the defined contribution plans. On the other hand, the majority of the public sector employers provide their workers with defined benefit plans (Gucciardi, 2009). The public sector provides its employees with both the defined contribution as well as the defined benefit plan. Conversely, the current trend indicates that the private sector is shifting away from the defined benefit to defined contribution plan. Further, the public sector employees receive subsidized health insurance benefits upon retirement, whereas the private sector employers do not offer such benefits to their retirees (Falk, Acs, Carrington, Dahl, & Jimmy, 2012). The number of private sector employers providing medical benefits to the retiree has declined considerably in the past decade. Over this period, the public sector employers have increased their medical benefits to the retirees despite the challenge of getting adequate funds to meet the

A growth strategy for Fifers Bakery Essay Example | Topics and Well Written Essays - 2750 words

A growth strategy for Fifers Bakery - Essay Example Fifers bakery is a large scale bakery supplying retailers with breads, cakes and other baked products. At present the company has no strategic plans for the next five year. To be able to develop a strategic plan the company should be aware of the key innovation trends and new product and category opportunities. A Growth Strategy should be planned to enable the company to anticipate the changes in the internal environment caused by the external environment in time. To start the process of selecting a market-dominating business and marketing strategy we must take the first four steps: Setting the vision for Fifers Bakery, gathering environmental and competitive intelligence, and identifying the strengths and weaknesses of the company.Fifers Bakery vision is to create business opportunities for both business owners and their employees to upgrade operations and increase both profits and wages. The company should be focusing on innovation that will lead the company into major growth. It i s also the company's focus to develop and produce new products that are not available in in-store bakeries and offer good customer service that has a personal touch in order to have customers coming back. The knowledge in information technology will be given importance since this will help the company to shorten its work from years to hours, minutes or seconds. Overall the vision of the company is to provide services that will benefit not only the company but its customers as well. To develop the best Growth Strategy for Fifers Bakery we must first understand the world outside the organization. Our focus will be our competitors, technology, market size and trends, our clients, availability of key resources (people and materials) and others that includes customer request and suggestions. Aside from the above mentioned external environment it also includes strategic implications for baking industry, category opportunities, new product opportunities and retailer and distribution drivers. Identifying the strength and weaknesses of Fifers Bakery includes the internal environment of the company. This includes the ability of the company to get new clients products and services, research and development , automation and equipments, knowledge and skills, employee diversity, capacity, training, company structure and culture, total Quality Management Systems, finance including cash flow, ROI leadership and others. From the above listed focus we will be able to start working on our Growth Strategy that will help Fifers Bakery survive or even lead the baking industry in the next five years. Topic The objective of this study is to be able to create a Growth Strategy for Fifers Bakery. The baking industry is complex, extremely competitive and fractious. The need for change and the focus for innovation are important. A Growth Strategy for Fifers Bakery will start at defining the company's goals. The attainment of such goal will mean that the vision has become a reality. It is best to identify first what markets we will do business. Since Fifers Bakery is a supplier for a retailer, then we will need to focus on those retailers who can cope up with the demand of the customers. We should not be only focusing on the orders; we should also overview the services being given to the customers. Baking industry has becoming very stiff that you need to improved or change some items in order to attract customers. We will be able to choose from being a marginal player with a small percentage or a big player with a significant portion of the market or we will dominate the market and crush all competition. It is important to identify which market we will focus. Customers play a vital role in the success of the organization. Fifers' bakery can make and bake the best cakes and bread in the world but if it is not what they need it would be a waste of time,

Portfolio Essay Example | Topics and Well Written Essays - 1000 words - 6

Portfolio - Essay Example ess surplus, they may be restricted to use it.Their main aim is not to be successful in terms of prosperity, but to give value to the groups of people they deal with. These organizations target to help people globally (Neal, 2001). Moreover, organizations are self-governing meaning they are separate from the government and they control their own activities and also non-compulsory involving some meaningful level of voluntary services. This is the attraction of funds from other sources to non-profit organizations. An organization’s resources are obtained from the communication of its needs. These organizations have different marketing strategies that are utilized to get money or revenues while spending little of what they have. For a non-profit organization to be financed it should determine whether the purpose of being financed is viable financially. It should ensure that it demonstrates some competitive advantage to ensure program viability. Marketers learn about the stakeholders who are involved for the course of the organization. The agency of these non-profit organizations understand the world of marketing and tactics more than they are given credits and are better than many institutions think and they need to be treated and also understand that an agency may need to raise funds. Communication program: According to McLeish (2011), marketing can be seen as a systematic philosophy and approach used in carrying out business. It is important to understand that marketing requires interacting business activities and reinforcing the premises that each area of management has a task to play to have a successful operation. Pricing: In non-profit organizations, price is the link between the resource allocation and the resource attraction. The company’s price of a product allows it to attract more resources than what they use in the production. Some of these organizations use more than one constituency donors and clients to get more resources for the day-to-day

Human experimentation Term Paper Example | Topics and Well Written Essays - 500 words

Human experimentation - Term Paper Example The actual collective and bottom-line benefit to society would be difficult to quantify. According to Goski (2011), â€Å"science-based medicine depends upon human experimentation†¦without human testing, they will never know if the end results of all that elegant science will actually do what it is intended to do and to make real human patients better. They will never know if the fruits of all that labor will actually cure disease. However, it is in human experimentation where the ethics of science most tend to clash with the mechanisms of science† (Goski, 2011, par. 1). Theoretically, scholars would have wanted to assert that human experimentation can be justified when greater good of society is at stake. This is actually the reason why several guidelines have been earmarked to establish rules that aim to adhere to ethical, moral, and legal standards with regards to using humans in experimentation (Kalechofsky, n.d.). The work of Ivy (1948), later known as the Nuremurg Code, explicitly stipuated guidelines in terms of observing quality of experiments, as well as the people conducting the experiments; and needed safeguards: Safeguards: (5) No experiment should risk death or disabling injury, "except, perhaps, in those experiments where the experimental physicians also serve as subjects;" (6) risk should never exceed the importance of the problem to be solved; (9, 10) experiment should be designed to be stopped at any point by: a) scientists if continuation is judged "liable to result in bringing disability or death to experimental subject; or b) by the human subject† (Ivy, 1948, pp. 1-5; cited in Kalechofsky, n.d.). From these guidelines, it could be deduced that the emphasis on the goal or outcome supposedly serving a utilitarian precept was most evident. In contemporary times, the need for informed consent has been stressed; but the controversial nature of potential

Reflective Analysis Essay Example | Topics and Well Written Essays - 500 words

Reflective Analysis - Essay Example d, highlight and report similarities of results and methods of research that is done in a particular subject matter over the specified number of years. Following are the analyses of works which I have done in the recent years. Finally, this report is intended for my parents and will be used as a means of communicating my educational progress to them. The first assignment was written to highlight the development of electronic and digital means by which humans can now take notes. The work also noted the adverse influences of the abovementioned technological interventions as people are not being to write manually when they have to while they also fail to remember spellings and commit lots of grammatical mistakes and errors in punctuation. On the positive side, the fashion of digital noting helped the students in the learning process because they can accumulate obscene amount of information both effectively and efficiently (Wang, 2). The work also had quite a few grammatical errors of its own but I am trying to overcome my weaknesses in regard to grammar by writing on a more frequent basis. The second assignment was nothing new but a refined form of the first one in which I duly attempted to control and manage quality of the content whereas I also put significant level of effort in terms of studying the subject in more detailed manner. I added that digital note taking is better as it allows the audience to record information with less effort. And there is nothing wrong in adopting new sand improved methods of taking notes as conventional ones are going to become obsolete in a few years from now (Wang, 2). Finally, the work suggested all people to master both traditional and modern techniques of note taking (Wang, 3) so that they will become capable of doing that despite of having technological difficulties that may render their modern devices inoperable. This review and analytical paper was developed in order to put my thinking ability to test and I put my best

Building a learning community project Essay Example | Topics and Well Written Essays - 3000 words

Building a learning community project - Essay Example ing at an age where plans for the future must be charted, the students’ perspectives for a fulfilling career are usually influenced by their interests and experiences. Hence, teachers must be knowledgeable in balancing teacher-directed learning and student-centred learning. A constructivist philosophy in the teaching-learning process is proposed. Ideally, career planning should begin early in a student’s life. As early as third or fourth grade, an Individual Career Development Plan (ICDP) should be started. This is a student notebook or portfolio containing information about their career interests including education and training opportunities and even exploration experiences (Hoerner, 1994). They are free to design their ICDP as they please because the more it is individualized to their preference, the more responsibility they will take in planning their lives, so they should be encouraged to carry their ICDP to all their classes, to take it home and share with parents, family and friends for feedback. Beginning a career plan in elementary school will help children have a focus around which they can relate their studies and extra-curricular activities. It is also important for teachers to nurture not only knowledge acquisition but also to include knowledge application. They need to think beyond the classroom and learn about possible careers their students may pursue when they go out into the world (Hoerner, 1994) Encouraging students to come up with their own ideas may be in the ambit of the teachers within the school premises. However, a bigger problem may lie outside school, specifically when the students go back to the community. The school, then, in envisioning success for such learner-centred learning must engage the community, most specifically the students’ parents and family members in supporting the students’ activities. Teachers must inculcate in the parents the significance of their cooperation and support if they indeed want their

Legal and Illegal Immigration in the U.S. Essay Example for Free

Legal and Illegal Immigration in the U.S. Essay Immigration Immigration in the United States has grown to an all time high. Now when someone hears the word immigration they automatically think of illegal immigrants from Mexico. But its people from all countries, legal and illegal. I will give my reasons why the United States should place more restrictions on immigrants. When the two World Trade Center towers where destroyed everyone immediately thought of terrorists. Later United States intelligence linked it to Osama Bin Laden. Bin Laden had his people from his army come to the United States and get information on how to carry out his plan. The terrorists even trained on U.S. soil to get more knowledge on how U.S. machinery, security, and aviation works. Now those terrorists came to America legally. Most of the immigrants come here illegally. I think that the U.S. should place troops on the Mexican boarder and the Canadian boarder to minimize the number of illegal immigrants entering the country. Now someone may argue that immigrants contribute to the strong U.S. economy by filling jobs, and even paying taxes. And that tighter restriction would compound the economic harm from the terrorist attacks. But the truth is the nation cant afford to have immigrants in the county when INS cannot track them. Furthermore more the immigrants have taken job opportunities from the native-born Americans, and lowered wages. Im sure that if the United States doesnt fix this problem the unemployment rate will grow much higher in our country. I feel that the United States should place much more restrictions on the people coming into the U.S. Legal and illegally. I have already said that many immigrants have taken many job opportunities away form the native born Americans and that the U.S. cant afford to track them. Now Im not saying that we should ban people from our country, but our nation needs to screen people much better then the way they are now.

Use Of Abiraterone In Castration Resistant Prostate Cancer Nursing Essay

Use Of Abiraterone In Castration Resistant Prostate Cancer Nursing Essay Prostate cancer is the most common type of cancer diagnosis of men in Canada. In 2012, approximately 26,500 men in Canada were diagnosed with prostate cancer and approximately 4,000 died from the disease . Prostate cancer is strongly influenced by androgenic steroids . In advanced stage prostate cancer patients are typically treated using androgen deprivation therapy. . Androgen therapy is not curative and may only improve patients symptoms and may even reduce metastatic lesions . The benefit seen in androgen deprivation is often reduced over years of androgen therapy as the tumour will continue to grow despite low androgen levels. When this occurs the tumour is known to be castration resistant and is known to lead to prostate cancer- related mortality . Castration-resistant prostate cancer (CRPC) may present as either a continuous rise in serum prostate- specific antigen levels (PSA), progression of pre-existing disease, or appearance of new metastases . Many endocrine based therapies have been evaluated for CRPC with minimal success in prolonging patient survival . Systemic nonhormonal therapies using docetaxel, carbaztaxel, and active cellular immunotherapy with sipuleucel-T have been shown to prolong survival . A new drug abiraterone (Zytiga) has shown to improve survival and lower PSA levels in patients with CRPC. This article is to be used by health professionals to gain a thorough understanding of abiraterones indication, mechanism of action, side effects, dosage, clinical evidence, monitoring parameters, and contraindications. Indication According to the product monograph for abiraterone the drug is indicated with prednisone for the treatment of CRPC in patients who have received prior chemotherapy containing docetaxel. Mechanism of Action Abiraterone is formulated as a prodrug, abiraterone acetate, which is converted to abiraterone by the body and acts as a selective inhibitor of 17ÃŽÂ ±-hydroxylase/C17,20-lyase (CYP17) . CYP17 is responsible for androgen biosynthesis in testicular, adrenal and prostatic tumor tissues . As illustrated in Figure 1, CYP17 catalyzes the conversion of pregnolone and progesterone into testosterone precursors, DHEA and androstenedione . The reduction in androgen production is beneficial for androgen-sensitive prostatic carcinoma. 722776-fig1.jpg Figure 1. Abiraterones mechanism of action in androgen synthesis Side Effects The most common side effects of abiraterone are caused by the mechanism of the drug on CYP17. As seen in Figure 2, inhibition of CYP17 causes on increase in the production of mineralocorticoids, which lead to hypokalemia, fluid retention, and hypertension . Other common side effects of abiraterone include myopathy, joint pain, abnormal liver function, hot flashes, diarrhea, urinary tract infections, bone fractures and cough . http://jco.ascopubs.org/content/28/9/1481/F4.large.jpg Figure 2. Effects of abiraterone on mineralocorticoid production . Dosage and Administration The recommended dosage of abiraterone is 1000 milligrams daily as a single dose . The tablets need to be swallowed whole and the dose should be taken on an empty stomach . To reduce the mineralocorticoid effects of abiraterone the patient should also use a low dose prednisone. The recommended dose or prednisone is 10 mg daily . Clinical Trials Evaluating Abiraterone The effectiveness of abiraterone in CRPC has been demonstrated in several randomized trials. In 2009, a study Attard et al., using forty-two chemotherapy-naÃÆ' ¯ve patients with CRPC received 1000 mg abiraterone . At follow up (median 505 days) a decline in PSA of à ¢Ã¢â‚¬ °Ã‚ ¥ 50% of was observed in 67% of patients, with declines of à ¢Ã¢â‚¬ °Ã‚ ¥ 90% in 19% of patients . A 2010 study by Danila et al., of fifty-eight men with CRPC previously on docetaxel received abiraterone 1000 mg daily with 5 mg of prednisone . Results of study illustrated that 36 % of patients had a PSA decline of à ¢Ã¢â‚¬ °Ã‚ ¥ 50% . In 2011, De Bono et al. conducted a study including 1195 patients who had previously received docetaxel . Groups were assigned in a 2:1 ratio to receive 5 mg of prednisone twice daily with either 1000 mg of abiraterone or placebo . The primary end point of the study was overall survival . The secondary endpoints of the study were time to prostate-specific antigen progression, progression-free survival according to radiological findings based on specified criteria, and PSA response rate . At a median 12.8 month follow-up overall survival was significantly longer in the abiraterone group compared to the placebo (14.8 months vs. 10.9 months, p. The secondary end points all favoured the treatment group; time to PSA progression (10.2 vs. 6.6 months; p. The studies using abiraterone in CRPC illustrate that the drug provides a moderate improvement in cancer progression and improves survival in patients. Monitoring Parameters Health professionals should place on emphasis of monitoring patients using abiraterone. Before treatment hypokalemia and hypertension must be normalized in patients who are scheduled to use the drug . It is important to routinely monitoring a patients blood pressure while they are on this product. Potassium levels should be checked at baseline and regularly to prevent hypokalemia in patients. Patients should also be checked for signs of fluid retention, such as peripheral edema. Liver function tests (ALT, AST, and bilirubin) should be measured prior to initiating abiraterone treatment and continued every two weeks for the first three months of treatment and monthly afterwards . Patients should routinely be assessed for other common side effects, including joint pain and urinary tract infections. Conclusion CRPC is a very advanced stage of prostate cancer that is fatal. Abiraterone (Zytiga) has been shown to prolong survival and lower PSA in men with CRPC. The drug works by selectively inhibiting CYP17 and lowering the production of testosterone via upstream inhibition of precursors in prostate, adrenal, testicular tissues. The selective inhibition of CYP17 leads to a large increase in mineralocorticoid activity in the body leading to hypertension, edema, and hypokalemia. The excess mineralocorticoid activity is typically diminished by administering 10 mg of prednisone daily with abiraterone. It is important to note that abiraterone is indicated as a second line therapy for patients who have failed treatment with docetaxel. While on abiraterone patients need to be monitored for hepatic function, hypertension, hypokalemia, and edema. .

Chinas Cultural Revolution: Reforms in the Education System

Chinas Cultural Revolution: Reforms in the Education System The period of the Cultural Revolution in China (1966-1969) witnessed a massive effort by the Maoist leadership to engineer the socialist transformation of Chinese society, one of the area most radically affected by the Cultural Revolution was the Chinese educational system. The Great Leap Forward has brought about much economic instability and lack of agricultural production, leading to the great famine. The goals and policies imposed by the government during the Cultural Revolution greatly decentralized the educational system and shifted focus from an industrial intensive production to an agricultural production. Although many rural schools continued to function throughout this period, formal education virtually ceased in the urban areas. In this paper, we will first take a look at the three main objectives in the educational reforms. With this general background description of the program, we hope to explain some of the goals that the Communist partied hoped to achieve. The second section of this paper will discuss the means that China employed to carry out the three main objectives, analyzing the decentralized manner in the implementation process and the structural impact it had on the educational system. Finally, we will evaluate the repercussion and critiques these reforms had on students and the society as a whole. Educational Reforms The Cultural Revolution had three basic objectives in reforming the educational system. In terms of the content of education, the first objective was to intensify ideological education so as to raise the political consciousness of the students. The second objective was to integrate theory and practice in the educational process in order to make education more responsive to the immediate production needs of the country. In terms of the scope of the educational system, the third objective was to popularize education, especially in the rural areas of China.[1] Prior to the Cultural Revolution, it seems that there was a tendency in Chinese education to emphasize technological and professional training often at the expense of the socialist revolution as envisioned by Chairman Mao. In 1956, with the exception of the third year of senior middle school in which a section of the constitution class was held each week, it was reported that political classes were entirely cancelled. This trend was further reinforced after the Great Leap Forward when educational policy emphasized more study and less work and politics. This general educational policy seems to have led to the consolidation of an elite technocracy drawn largely from the educated bourgeois elements of the past. Thus, the most important goal of educational reform in the Cultural Revolution was to mobilize the students and raise to a higher level their awareness of class contradictions still existing in Chinese society. As Mao made clear, all work in school is for changing the thinking of the student.[2] This educational objective was part of the massive effort of the Cultural Revolution as a whole to revitalize the commitment of the country to the socialist transformation of society. The economic objectives of the educational reforms of the Cultural Revolution should be seen within the context of the overall strategy for economic development. The emphasis on integrating theory with practice, or education with production, was not new in itself. The Ministry of Education stated explicitly in 1950 that the purpose of institutions of higher learning in the Peoples Republic of China is to train high level specialists for national reconstruction in accordance with the principles of the Cultural and Educational policy included in the Common Program of the Peoples Political Consultative Conference of China, and using a method which combines theory and practice. These specialists will have advanced standards of culture, will master modern science and technology, and will have total dedication to serving the people.[3] However, the way in which theory was linked to practice was quite different from that which Mao had in mind for the Cultural Revolution. And the problem her e was not simply one of implementation but of basically different concepts of economic development. From 1949 to 1958, Chinas strategy for economic development essentially followed that of the Soviet model, which stressed the growth of heavy industry at the expense of light industry and agriculture. As bottlenecks began to form, China began searching for alternative developmental strategies. Thus, the Great Leap Forward was an attempt to mobilize the masses on a large and intensive scale to break the bottlenecks in the economy. While this strategy as a whole failed, it marked the point at which China changed from its previous strategy to one placing relatively more emphasis on rural development. This change in developmental strategy brought a basic change in the definition of what practice constituted in the educational process. In one case, it meant working in the industrial sector primarily in a technological capacity, while in the other, it meant working in the fields to increase rural production. Thus, in the former case, linking theory and practice meant training more highly s killed specialists to advance the technology for Chinas heavy industry, while in the latter, it meant training less-highly skilled generalists in less time to meet the local production needs of the rural sector. Thus, the economic objectives of the educational reforms were oriented primarily to the development of agriculture and light industry. Up until 1966, educational opportunities, particularly at the higher levels, remained unduly concentrated in the big cities. The rural areas, despite some improvements since 1949, did not benefit from educational expansion to nearly the same degree as the urban areas.[4] In fact, according to a Russian source, after initial success at popularization of educational opportunities between 1950 and 1958, the number of students at all levels of education decreased markedly from 1960 to 1965. It was also said that Liu Shaoqi admitted that in the 1965-66 school year approximately 30% of the children in China were not covered by a system of primary education.[5] This bleak picture was partially confirmed by the Peoples Daily report that in 1965, 30 million school-aged children were not in school, most of them being rural children.[6] Thus, one of the major objectives of the educational reforms was to correct this situation by increasing the number of schools in the rural areas and initiating a large scale recruitment of peasants and workers into the existing educational system. Means of the Reforms The implementation of educational reforms was carried out via a decentralized process, as most schools were placed under local management. In fact, it was reported in 1973 that each school had its own Revolution in Education Committee responsible not only for implementing reforms but also for part of the planning process within its own institution.[7] So it would seem that local experimentation within the general framework of the new educational policies was encouraged. Experimentation was seen as necessary primarily because of the emphasis on adopting flexible methods to meet the diverse needs of different schools and regions. We will identify below the major guidelines regarding the implementation of the educational reforms, as well as describe some of the different ways the reforms were implemented. In order to elevate the political consciousness of the students, the curriculum was heavily stocked with political education courses. The major texts used were drawn from the works of Mao. Aside from increasing the number of political course, other courses also drew upon Maos thoughts to explain various approaches to the analysis of whatever phenomenon was involved.[8] This reliance on Maos thoughts was essentially the concept of putting politics in command of knowledge. At the same time, revolutionary mass criticism and class struggles were actively promoted to bring into sharp relief the various contradictions in society from a more personal perspective. The principal means of linking theory and practice in the educational process were to make production labor a major part of the students curriculum and to direct research to meet local needs. These methods were based on the concept of practical training, although their implementation in China seems to have gone far beyond that prac ticed by other countries. In the rural areas, students would spend much of their time working in the fields and learning from the peasants. The training of the students included clearing marginal lands, planting and harvesting, working on the construction of water conservation projects and irrigation systems and so on. [9]Research in turn was directed towards increasing the crop yield and the mechanization of the local production units. What the specific tasks would be depended on the particular needs of a given locality. As for the urban sector, secondary and higher learning institutions were reported to have set up local factories within the schools not only to train students in practical work, but also to engage in significant production work. In other cases, factories and schools established ties with one another so as to direct the research of the latter to the needs of the former, making possible the immediate application of new findings. At the same time, veteran workers were often brought to the schoo ls to teach in certain areas and students worked at the factories for practical training. Some factories even established schools of their own, although this method seems to have more or less faded out. In brief, the educational reforms designed to attain the economic objectives basically gave the students more practical training and actual work in production than did the previous educational system. It was said that prior to the Cultural Revolution, peasants and workers had much difficulty attending schools because of such obstacles as high entrance examination standards (primarily for colleges and universities), high costs and expenses, inaccessibility since most schools were located in the cities, conflict of class schedules with local production time tables, and the lack of direct and immediate relevance of the courses offered to local production needs. As a result, educational opportunities were still not extended to many in the country living in the rural areas. During the Cultural Revolution, many of the reforms were implemented specifically to erase such barriers to education. Some of the broad guidelines for popularizing education were: 1) lowering educational standards, thus making possible the large scale recruitment of peasants and workers into the existing educational system, and especially to higher learning institutions; 2) lowering educational fees and expenses; 3) shortening the number of years for a basic education, usually from a 6-3-3 to a 5-2-2 system, while higher education was usually reduced from four or five years to two or three years (this allowed more to enter the educational system since less time would be taken off needed production work and the school population would be reduced for a given amount of students going through); 4) promoting popularly-sponsored schools-this expansion occurred mainly in the rural areas and was limited basically to the primary school level; 5) adapting curriculum and schedules to local req uirements; and 6) simplifying teaching materials.[10] Within these reform guidelines, however, schools at all levels could experiment with different ways of implementing the reforms. For example, Peking University with its more carefully selected students continued to have higher standards of education than many other colleges and universities. However, an attempt was made to lessen the gap.[11] Or with regard to popularly sponsored schools, there arose mobile schools, spare-time schools, half-work, half-study schools and so on. Furthermore, the specific curriculum of each school, except perhaps for the political education courses, varied according to the needs of the particular region. Thus, the popularization of education was carried out under a flexible and decentralized educational system. Repercussion of the Reforms While the drastic educational reform measures have given peasants opportunities to attain basic education in rural areas, as well as agricultural production and political gains, it naturally came with lasting negative impacts that promoted many post-modernists critiques. In the beginning of the Cultural Revolution, values like collaboration, diligence, modesty, and respect for elders and teachers were discarded as a result of the purge of the old Chinese cultures and traditions. Many have failed to retain the virtues during the revolution. Second, due to political struggle and line drawn between working classes and intellectuals, as well as political and violent nature of the social revolution, substantial innocent teachers and professionals were subjected to personal attacks and humiliation, some even executed. Third, specific strategies of the reformed curriculum and examination system proved to be misguided and wasted the schooling of many young people. The disconnection between a cademic achievement and students future career, the emphasis on political correctness over academic achievement, and the neglecting of theory learning and over-emphasis on hands-on experiences were all examples of poor decisions. Fourth, the Cultural Revolution both liberated students and dominated them. It liberated students and people because it opened their eyes to the inequality existing in education and society; However, it imposed political control and dominated them because it did not allow real democratic, independent and critical thinking ability.[12] As Freire (1970) put it, If teachers help students from oppressed communities to read the word but do not also teach them to read the world, students might become literate in a technical sense but will remain passive objects of history rather than active subjects.[13] Conclusion The Cultural Revolution opened peoples eyes but imposed the governments intentions on the people and dictated their thinking. Thus, people were forced to follow the governments ideology. In accordance with the three objectives set forth by the Communist Party, strategies were carried out in a decentralized manner that placed significant amount of decision making on local management. To raise political awareness, much of the curriculum were inspired by Maos thinking. His principles such as practice training were also preached to the students, which compliments well with the second objective; to integrate theory and practice while increasing agricultural production. At the time, schools and factories were tightly assimilated, as much of the students from urban areas were organized to work in rural areas, in order to experience the real China and raise consciousness on the large class segregation that existed. Lastly, with adjustments to the curriculum schedules, time commitment, academ ic and financial requirements, the barriers to entry were significantly reduced for many rural youths. Basic education was finally attainable by peasants and popularized in the rural area. However, this caused a reduction of higher education and development of specialized skilled workers in the urban area, in accordance with the focus on agricultural production rather than industrial production. The extremist nature of the reforms achieved by China was unlike what other countries could have accomplish. While political agendas and production goals were met, it came at a great cost to students that lasted through the generation. Connections to their ancestors culture and virtues were cut in favor of Maos thinking and the way of the new China. This led to activities that post-modernists could consider contradictive to the development of humanity, which was evident in the case of innocent individuals who retained the old culture or decided against Maos thinking were humiliated or executed. Students freedom of critical thinking was taken away, replaced by political correctness and over-emphasis on hand-on experiences, ultimately hindering their theoretical knowledge and future career development. Bibliography Seybolt, Peter. Editors Introduction, 1971 Huey, Alison B. The Revolutionary Committee of Peking Middle School #31, 1970 Gardner and Idema, Chinas Educational Revolution, Cambridge Univ. Press, 1973 Klepikoy, V. Z. The Fate of Public Education in China, Sovetskaia Pedagoka #8, 1968, translated by J.ÂÂ   Barry Eliot, CE 1 Peoples Daily, Chinas Educational Revolution, 1965 McCormick, Robert. Revolution in Education Committees, The China Quarterly #57, 1974 Wuyuan Rev. Comm. et al., A New Type of School That Combines. Theory with Practice, 1968 Yu-lin Special Region Rev. Comm. and Kuei-ping Rev. Comm, Train Workers to Have Socialist Consciousness and Culture, 1970, Wan, Guofang. The Educational Reforms in the Cultural Revolution in China: A Postmodern Critique, 1998. https://eric.ed.gov/?id=ED427419 Lankshear, C. and Mclaren, P.L. Critical Literacy, New York: State University of New York Press, 1993 Shor, I. Empowering Education, Chicago: The University of Chicago Press, 1992. [1] Peter Seybolt, Editors Introduction, 1971, p. 4. [2] Alison B. Huey, The Revolutionary Committee of Peking Middle School #31, 1970, p. 206. [3] Seybolt, p. 4. [4] Gardner and Idema, Chinas Educational Revolution, Cambridge Univ. Press, 1973, p. 257 [5] V. Z. Klepikoy, The Fate of Public Education in China, Sovetskaia Pedagoka #8, 1968, trans, J. Barry Eliot, CE 1, p. 42. [6] Peoples Daily, Chinas Educational Revolution, 1965, p. 258. [7] Robert McCormick, Revolution in Education Committees, The China Quarterly #57,1974, p. 133. [8] Wuyuan Rev. Comm. et al., A New Type of School That Combines. Theory with Practice, 1968, p. 24-31 [9] Yu-lin Special Region Rev. Comm. and Kuei-ping Rev. Comm, Train Workers to Have Socialist Consciousness and Culture, 1970, p. 40-45 [10] Gardner and Idema, p. 279-280. [11] Ibid., p. 286. [12] Wan, Guofang. The Educational Reforms in the Cultural Revolution in China: A Postmodern Critique, 1998. [13] Lankshear, C. and Mclaren, P.L., Critical Literacy, New York: State University of New York Press., 1993

Technology Advances Enterprise-Wide Planning Essay -- Technology Busin

Technology Advances Enterprise-Wide Planning Enterprise resource planning (ERP) systems utilize internal and external management information across an entire organization (Alshare & Lane, 2011). This systems embraces finance/accounting, manufacturing, sales and service, customer relationship management, and many more. The ERP system uses an integrated software application that helps the system to become automated. Its purpose is to facilitate the flow of information between all business functions inside the boundaries of the organization and manage the connections to outside stakeholders (Alshare & Lane, 2011). ERP systems typically include the following characteristics: a complex system that operates in real time without relying on periodic updates, a common database that supports all functions, a consistent model throughout each module and installation of the system without much hassle and development (Wixom, Watson & Werner, 2011). In 1990 Gartner Group first carried out the ERP as an extension of material requirements planning and ERP came to represent a larger whole, reflecting the evolution of application integration beyond manufacturing (Alshare & Lane, 2011). By the mid–1990s ERP systems addressed all core functions of an enterprise. Governments and non–profit organizations also began to employ ERP systems. The ERP systems experienced rapid growth in the 1990s because the year 2000 problem and introduction of the Euro disrupted legacy systems. Many companies took this opportunity to replace such systems with ERP. This rapid growth in sales was followed by a slump in 1999 after these issues had been addressed. The ERP systems, in the beginning, focused on automating back office functions that did not directly af... ...eed to take this into consideration. In the deployment presented in this paper, we have achieved ROI in both R2R control and FDC related to the early deployment phases. The APC technical and business models will allow organizations to complete the remaining phases, and migrate into new areas such as fault prediction and APC incorporation with yield management. References Alshare, K. A., & Lane, P. L. (2011). Predicting Student-Perceived Learning Outcomes and Satisfaction in ERP Courses: An Empirical Investigation. Communications of AIS, 2011(28), 571-584. Wixom, B. H., Watson, H. J., & Werner, T. (2011). Developing an enterprise business intelligence capability: The norfolk southern journey. MIS Quarterly Executive, 10(2), 61-71. Moyne, J. (2009). A blueprint for enterprise-wide deployment of advanced process control. Solid State Technology, 52(7), 35-37.

Surface Tension :: essays research papers fc

Surface Tension   Ã‚  Ã‚  Ã‚  Ã‚  My problem was to find out how to test or measure surface tension. I think the reason of some of the force in surface tension is cohesion and gravity. Surface Tension is the condition existing at the free surface of a liquid, resembling the properties of an elastic skin under tension. The tension is the result of intermolecular forces exerting an unbalanced inward pull on the individual surface molecules; this is reflected in the considerable curvature at those edges where the liquid is in contact with the wall of a vessel. Because of this property, certain insects can stand on the surface of water. A razor blade can also be supported by the surface tension of water. The razor blade is not floating: if pushed through the surface, it sinks through the water. More specifically, the tension is the force per unit length of any straight line on the liquid surface that the surface layers on the opposite sides of the line exert upon each other. The tendency of any liquid surface is to become as small as possible as a result of this tension, as in the case of mercury, which forms an almost round ball when a small quantity is placed on a horizontal surface. The near-perfect spherical shape of a soap bubble, which is the result of the distribution of tension on the thin film of soap, is another example of this force; surface tension alone can support a needle placed horizontally on a water surface.   Ã‚  Ã‚  Ã‚  Ã‚  Surface tension depends mainly upon the forces attraction between the particles within the given liquid and also upon the gas, solid, or liquid in contact with it. The molecules in a drop of water, for example, attract each other weakly. Water molecules well inside the drop may be thought of as being attracted equally in all directions by the surrounding molecules. However if surface molecules could be displaced slightly outward from the surface, they would be attracted back by the near by molecules. The energy responsible for the phenomenon of surface tension may be thought of as approximately equilivant to the work or energy required to remove the surface layer of molecules in a unit area. In comparison, organic liquids, such as benzene and alcohol's, have lower surface tensions, whereas mercury has a higher surface tension . An increase in temperature lowers the net force of attraction among molecules and hence decreases surface tension.   Ã‚  Ã‚  Ã‚  Ã‚  Surface tension is also viewed as the result of forces acting in the plane of the surface and tending to minimize its area. On this basis.

Quest for Self-Identity in Margaret Atwood’s Surfacing and The Bell Jar

As the post-colonial criticism developed, the theorists have agreed upon the fact that the role of feminism in the post-colonial practice is crucial. Moreover, these two theories clearly have the same goals. On the one hand, the main objective of both of them is to disclose the traditional power structures, both patriarchal and imperial. On the other hand, both feminism and post-colonial criticism aim to show the way the writers challenge the respective forms of authority. The main concerns of the post-colonial criticism are the formation of canon, the phases through which imperialism and decolonization have gone, as well as how these processes are expressed in literature. What is more, the criticism is also concerned with the ways of resistance within literary pieces, such as rewritings of traditional concepts and creating voices that stand in opposition. All these issues become the matrix and concern of feminist criticism. Not the least, crucial to feminism is also pointing at the notion of diversity. For many women, the process of writing is an expression of themselves, it allows them to â€Å"throw off their chains† and to struggle for more autonomy. The twentieth century has given rise to women’s efforts to fight for their rights in the Western world. In the forties, they were relatively emancipated, since they perceived the encouragements to enter the workplace. There, they could enjoy a relative independence and they felt responsible. They proved that they can be â€Å"effectual workers†, but when the World War II was over, they had to face new requirements: they had to give up the jobs to the males coming back from the war (â€Å"Feminism†). They were and felt misplaced, everyone expected them to take care of their homeplace instead. ... ..., Eadaoin. â€Å"Colonialism in Margaret Atwood’s Surfacing.† 12 Apr. 2003. Aspenlieder, Erin. â€Å"Tips for Surviving ‘Atwood’: Confronting the Complexities of the Wilderness Celebrity.† Margaret Atwood Studies. 3.1 (Sept. 2009): 3-11. Benson, E., and L.W. Conolly, â€Å"Routledge Encyclopedia of Post-Colonial Literatures in English. London: Routledge, 1994. Cheadle, Richard. â€Å"On: Margaret Atwood’s Surfacing.† 2006. 3 June 2010 Parker, Ema. â€Å"You Are What You Eat: The Politics of Eating in the Novels of Margaret† . Atwood.† Twentieth Century Literature. June 10, 2010. Perloff, Marjori (Autumn 1972). â€Å"A Ritual for Being Born Twice": Sylvia Plath's The Bell Jar". Contemporary Literature (University of Wisconsin Press), March 13, 2012. Wagner-Martin, Linda (1988). Sylvia Plath, the Critical Heritage. New York: Routledge, May 21, 2001.

The Characteristics Of Adult Learners Education Essay

Adult pupils in the procedure of ELT construct the particular group of people socially accepted as mature and who are in a learning procedure. Education of grownups has long been perceived as different from instruction of kids in both theory and pattern. The field of big instruction was pioneered by Malcom Knowles who claimed that andragogy should be distinguished from teaching method. Andragogy consists of larning schemes focused on grownups while teaching method is concerned on kids. Knowles ‘ theory of andragogy is an effort to develop a theory specifically for grownup acquisition. Adults bring life experience and a degree of adulthood into the schoolroom that kids and striplings do non. Probably the individual most of import concern for the instructor of grownups is a thorough apprehension of the scholar. Through such an apprehension it is possible to direct your learning to the specific demands and involvements of the grownup. Adults are autonomous and expect to take duty for determinations. Adult larning plans must suit this cardinal facet. In practical footings, it means that direction for grownups demands to concentrate more on the procedure and less on the content being taught. It is of import to utilize schemes such as function playing, simulations, undertaking work and treatments rather frequently because they are most utile for big pupils who are job -centred, goal- oriented and practical. Teacher adopts a function of facilitator or resource instead than lector or grader. Furthermore, another facet of grownup instruction is motive because merely when pupils are motivated they can larn. The best manner is to heighten studentsA? ground for larning. Teachers must be after their motivation scheme which is considered to be successful if it includes demoing grownup pupils the relationship between developing an expected publicity. Finally, we do non hold to bury another built-in portion of grownups larning which proper feedback is. We should cognize when and have to give feedback because good feedback is one of the basic wagess of acquisition. Teaching English to grownups is different from learning kids and teens and involves a considerable sum of planning and accomplishment to do it apprehensible and adaptable to all scholars.1. Features of Adult LearnersCompared to kids and teens, grownups have particular demands and demands as scholars. Adults are people who have the position of adulthood in their ain and other peopleA?s eyes, but in the instruction procedure they come in the low-level place of the scholars. It could be really hard at the beginning and it depends on persons how to cover with this state of affairs. A batch of grownups can go dying because they are so disquieted about traveling back to school and are afraid of their failure and may believe that they are unable to larn. â€Å" The struggle is that as grownups we already have certain well-developed thoughts about life along with our ain system of thoughts and beliefs. To acknowledge that we need to larn something new is to acknowledge that there is something incorrect with our present system. â€Å"[ 1 ] On the other manus, they have outlook about the acquisition procedure and they are able to accept duty for their ain acquisition. They are independent and self – directed, they are non dependent on other people for way. Adults as scholars are goal-oriented and results-oriented. They normally know what end they want to accomplish and they besides have specific consequences in head for instruction. They must see a ground why to larn something. Learning has to be valuable for them ; it should be related to their demands and eventually suit to their work. In other words, grownups seek instruction which is appropriate for their current lives. They are practical and are focused on the facets of the lessons ; it means they want to cognize how the lessons will be utile to them on the occupation. We must non bury that grownups have a batch of experience and a wealth of cognition and they expect to be treated consequently. They require larning that makes sense and is connected to their cognition and experience. They can be critical of learning methods ; they will non execute a learning activity merely because the instructor said to make it. Furthermore, we can anticipate that grownups are more disciplined that some kids and adolescents and are able to prolong a degree of motive. Compared to kids, grownups have more developed abstract idea ; it means we have to take appropriate activities adapted to utilize their minds to larn consciously. To sum it up, there are a batch of specific characteristics of grownup scholars which we have to bear in head in the procedure of learning. Compared to kids and adolescents, grownups have particular demands and demands as scholars. Of class, these are generalisations and there can look some exclusions in each group of scholars.2. Learner DifferencesAll pupils have different rational abilities. They think and learn otherwise. Learner differences are related to different thought manners and larning manners of pupils. Some of them use more than one manner, but by and large each individual has a preferable manner. We can separate brooding minds, originative minds, practical minds and conceptual minds. Brooding minds perceive new information subjectively, associate it to past experience and analyze their feelings about larning. On the contrary, originative minds like to play with new information, really frequently ask â€Å" why? † and make their ain solutions. Practical minds need factual information and attempt to happen the simplest and besides efficient manner to make something. In other words, they want to use their new accomplishments to their occupation. The last group consists of conceptual minds who are interested in how things work, non merely in the concluding result. They like seeing images and want to cognize the related constructs.[ 2 ] Equally of import are larning manners. Students normally tend to one acquisition manner because they associate it with larning success. There are three general larning manners: ocular, audile, and kinesthetic. Ocular scholars process new information when they can see it. They like artworks, illustrations, diagrams, images and presentations. Their slogan is â€Å" Show me. â€Å" Auditory scholars rely on sounds and voices ; they remember new information when it is spoken. They love talks and treatments. Their slogan is â€Å" Tell me. † Kinesthetic scholars need to make something to understand it. They want to touch the new information or manipulate it. They prefer written assignments, taking notes and scrutiny of objects. Their slogan is â€Å" Let me make it. †3. Motivation for Adult LearningMotivation is some sort of internal thrust which pushes person to make things in order to accomplish something. A cognitive position of motive includes factors such as the deman d for geographic expedition, activity, stimulation, new cognition and self-importance sweetening. Students come to education for many grounds. All grounds are acceptable because any motive is better than none. Unless you are motivated, you will non and can non larn. Most big pupils are at the schoolroom because they want to be. There are called â€Å" want to † scholars. Some of them are at that place because they need it for their occupation. They are â€Å" have to † scholars. There are a batch of motive factors. Some of the most common are: Promotion- depends on go throughing an test or making a class. Personal promotion – people want to acquire higher position at work. Social relationships – people want to do new friends. Escape/Stimulation – people want to avoid ennui, larning can disrupt the day-to-day modus operandi at place or at work. External outlooks – people try to carry through the outlooks of person with formal authorization. More money – after go throughing a class or successful graduation you can anticipate to gain more money. Social public assistance – attempt to better ability to be good to mankind and take part in community work Cognitive involvement – people who are interested in larning, they want to have new information and seek cognition for its ain interest There are Four Foundational Principles that motivate grownups to larn ( Wlodkowski, 2009 ) : Inclusion is the consciousness of scholars that they are a portion of an environment, they respect each other, and they have no fright of menace or humiliation. It is related to positive societal clime. Inclusion Fosters engagement. Attitude is a combination of constructs, information, and emotions. Attitude consequences in a sensitivity that can take to favorable or unfavorable response. Attitude causes a powerful consequence on human behavior and acquisition because they help people make sense of their universe. ( E.g. Negative larning experience can impact our attitude, engagement and outlooks. ) Meaning – devising, apprehension, and altering significance is a cardinal facet of grownup instruction. Deep significance causes that the experience or thought is connected to an of import end. Meaning comes from disputing larning experience in an piquant format about a relevant subject. Meaning sustains engagement. Competence is an attempt to effectual interaction with the universe. Adults have a strong innate temperament to be competent. They need to use what they have learned to the existent universe. Competence allows a pupil to experience confident when they know that they are expert at what they are larning. Assurance once more supports and motivates more extended acquisition. This can ensue in a spiralling moral force of competency and assurance. Increasing and directing pupil motive is one of a teacherA?s undertakings. We should form the indispensable motivational conditions. If we want to set up inclusion, we need to make a acquisition ambiance in which scholars and instructors feel respected and connected to one another. Following undertaking is to develop attitude, it means making a favorable temperament to larning through personal relevancy and pick. To heighten significance is of import to make ambitious and thoughtful acquisition experiences which include learnersA? positions and values. Furthermore we should breed competency by making an apprehension of scholar effectivity. And how do we cognize if scholars are motivated? There are some discernible indexs of intrinsic motive: Learners do activities without opposition. Learners spontaneously relate acquisition. Learners ask inquiries. Learners go beyond required work. Learners are proud of their acquisition and its effects. Unlike kids and adolescents, grownups have many duties that they must equilibrate. These duties can take to the barriers against take parting in larning. The most common jobs are deficiency of clip, money, assurance, involvement, deficiency of information, programming job and jobs with kid attention and transit. The best manner how to actuate grownup scholars is to heighten their ground for acquisition and diminish the barriers. As instructors of grownups we have to be after actuating schemes which show learners the relationship between preparation and an expected publicity.4. Giving Feedbackâ€Å" The old expression that pattern makes perfect is non true. But it is true to state that it is pattern the consequences of which are known which makes perfect. † ( F.C. Barlett ) Feedback, unfavorable judgment, praising and noticing are really of import in the instruction procedure. Teaching grownups is complicated because of the trouble of knocking. There are two unsafe: giving feedback in the incorrect manner and non giving plenty. Without proper feedback the learner public presentation can non better. If public presentation can non better, all scholars rapidly loose their involvement. Good feedback is one of the basic wagess of acquisition and critical portion of the learning rhythm goes like this: In comparing with kids and teens, grownups find it harder to acknowledge that they have made a error, and it is harder for them to unlearn it. The same error can be repeated once more hence is of import to give feedback instantly or every bit shortly as possible. The job is non merely to rectify mistakes made on the topographic point, but to happen out some basic misinterpretations from the yesteryear, e.g. when we teach grammar, pupils sometimes have no thought what parts of address are. Until all the misinterpretation from the yesteryear are identified, no advancement can be made. A batch of pupils seem it hard to larn the regulations of English spelling decently. It can be a combination of mechanical and psychological grounds. It is peculiarly difficult to rectify once more perennial errors. The solution how to avoid it is bar ; it means make certain that on first juncture of a new piece of larning the grownup gets the right reply – â€Å" right first clip † .[ 3 ] It is frequently said that people learn by doing errors. It is true but we should recognize when measuring that prise make us experience confident, whereas negative unfavorable judgment makes us self-doubting. Good feedback is given quickly, contains encouraging words, gives elaborate remark on each public presentation, praises the good points before knocking the bed, is focused on knocking the public presentation, non the individual, is concentrated on merely a few errors at a clip and is clear. Giving feedback demands accomplishments every bit good as tact. We should make a friendly ambiance for constructive feedback. After giving feedback, we should look into that the scholar has understood the message by inquiring open-ended inquiries. Avoid closed ( yes, no ) inquiries, e.g. Have you understood? It is better to get down inquiries with â€Å" State me † , â€Å" How † , or â€Å" Why † . Finally, a batch of instructors overestimate the measure of feedback they give. To avoid it, seek to happen ways to offer every scholar some feedback in every lesson. As instructors of grownups we should understate the bed consequence of unfavorable judgment although there are a batch of possibilities for misinterpretation because without feedback pupils can non larn and instructors do non learn.5. Function of the Teacherâ€Å" When the pupil is ready, the instructor appears † ( a Buddhist adage ) As we said in one of old chapter, a batch of big pupils can experience dying when they go back to school after a few old ages being out of the schoolroom. Our occupation as a instructor of grownup pupils is to be positive, friendly and encouraging. Patients help excessively. It is sometimes of import to cognize that older pupils need more clip to react if we ask a inquiry. Promote your pupils to utilize their ain life experience in the acquisition procedure excessively. As instructor we should understate the carnival of failure and the bad consequence of past acquisition experiences by offering activities which are accomplishable for our pupils and correspond to their degree. Not merely pupils can hold some concerns. There can be a job for some instructors and it is age. School instructors are ever older than their students and have the advantages of longer instruction. Not so instructors of grownups. They can be younger than their pupils and may even be less intelligent. It is right to hold some concerns about a new group of pupils, but both the job and the solution are in our ain custodies. What makes a good instructor? Effective instructor have these features ( Rogers, 1989 ) : A warm personality – accept all pupils and understand them, be helpful Social skill – ability to link the group together without being dominate Forming ability – disposal is swimmingly handled Skill in descrying and deciding scholar jobs Enthusiasm – a batch of oculus contact, varied voice inflection. Not merely can the personality of a instructor but the leading manner lead to the success or failure of larning. We can separate three different types of leading: dictator, where the leader is rigorous, autocratic, encourages fight and makes all of import determinations himself ; laissez-faire, where the instructor does virtually nil unless he is straight asked a inquiry ; and democratic, where the scholars decide what they will make and the instructor is person who can impact single solutions of jobs. In the group where the instructor behaves magisterially the scholars are submissive and good behaved, but frequently mishear instructions, are competitory, reciprocally belittling and demo marks of aggression and tend to abandon work when the instructor leaves the room. On the contrary, the individualistic group does about nil whether or non the instructor is present. Under democratic leading the scholars work good together without carnival of one surpassing the other. There occur smal l tenseness or aggression and the impermanent absence of the instructor make no alterations in the sum of work the scholars do.[ 4 ] It is clear that creativeness is more bucked up in groups where the instructor does non rule. There can develop pleasant societal relationships, more pupils talk to one another and esteem each other. On the other manus, dominant, aloof, autocratic instructors tend to bring forth either really hostile or subdued group of scholars who are individualists and do non desire to co-operate.6. Teaching SchemesAny activity that gets pupils involved is really utile and makes the learning experimental. This includes e.g. little group treatments, function drama, composing or pulling something specific, skits etc. Activities that involve acquiring up and traveling approximately can besides maintain pupils energized. Try to utilize a assortment of learning stuffs and methods and do non bury single differences of your pupils ( differences in manner, clip, types and gait of larning ) . It is known that single differences addition with age. Take into history that your pupils have a batch of life expe rience which they can convey to the schoolroom, supply them every bit much chances for duologue as possible and ask open-ended inquiries so that they can utilize their cognition and experience. Treat all inquiries and remarks with regard. State your pupils the outlooks of the instruction procedure and familiarise them with the course of study, but do non be disappointed when they do non wholly agree with your program. You can discourse it together and do some alterations in conformity with the demands of your pupils. They can assist you to plan the acquisition procedure. Because grownup pupils are jobs centred, allow them cognize how the freshly acquired cognition can be applied to current jobs or state of affairss. As a instructor you should equilibrate between presentation of new stuff, treatment and engagement among pupils and your class program. Teaching schemes for grownups are more effectual if it is learner-centred than instructor-centred.[ 5 ] By utilizing combinations of grownup scholar techniques and schemes, Extension pedagogues can make preparation experiences that will heighten the acquisition of participants. When grownups participate in a positive acquisition experience, they are more likely to retain what they have learned and use it in their work environment.6.1. Lectures and PresentationsLectures and presentations are the most common instruction methods in big instruction. They are sometimes referred to as an economic manner of learning because they do non necessitate about any technician or administrative support. As a instructor usage these methods exhaustively. First, maintain them short. Lectures should take 15 or 20 proceedingss and bound for presentation is even shorter, five proceedingss. Second, your talk should hold a clear beginning, center and terminal ; it means that it is clear to your pupils and if it is clear defined, it can assist pupils to cognize what the aims are before get downing. This techni ques has o batch of possibilities how to be used. You can present short intensive presentation which is followed by practising. You can instantly see if your pupils understood your talk. Adults learn best through engagement and activity, so your talk or presentation can be interspersed with group treatment, single undertakings, and audio-visual stuff. In the talks or presentations try to maintain to simple chief points. A batch of grownup pupils need to hold a written support of a new piece of larning but it is known that grownups do non take notes really frequently. Making notes during presentation can be a recreation from understanding therefore it is better to teach your pupils non to compose merely listen to you. Fix well-designed printed press releases for them, non really long because it could deter your pupils from reading it. It is better to administer press releases after a talk than earlier ; it is less deflecting. If you are showing, be certain that all scholars are able to see from your point of position. If the presentations are seen from the forepart, the pupil must mentally change by reversal all the procedures. In general, talks and presentations are likely best used in short subdivisions, with frequent resort to treatment, single pattern, undertaking work etc.6.2. Role – drama, Simulation and GamesSimulation, role- drama and games play similar functions in linguistic communication instruction. They are seen as ways of bridging the spread between the schoolroom and the existent word. These activities offer a assortment of ways how to do the acquisition procedure more interesting, disputing and lively. As we said in earlier chapters, grownups need to avoid being told how to make something, they need to seek it out for themselves. Role-playing refers to the changing of one ‘s behavior to presume a function. It is any speech production activity when you either set yourself into person else ‘s places ( The President, a millionaire, a dad star etc. ) , or when you stay in your ain places but set yourself into an fanciful state of affairs ( ‘At the eating house ‘ , ‘Checking in at the airdrome ‘ etc. ) Role-playing is proposed as an ideal technique to learn linguistic communication because it prepares scholars for the unpredictable nature of real-life communicating, Teachs appropriate linguistic communication usage, and boosts assurance. Learning takes topographic point when activities are prosecuting and memorable. It is ever better to convey state of affairss to life and maintain them existent and relevant. We should utilize the role-play for the undermentioned grounds ( Harmer, 1989 ) : It ‘s merriment and motivation. Quieter pupils get the opportunity to show themselves in a more blunt manner. The universe of the schoolroom is broadened to include the outside universe – therefore offering a much wider scope of linguistic communication chances. Some function playing is simple and does non necessitate any particular readying. It is a normal extension of work done rehearsing duologues and drills ; on the other manus, function drama can be prepared in advanced when the instructor sets up the scene. The stuff must be relevant, brief and believable. Once you have selected a suited function drama, predict the linguistic communication needed for it. It is recommended to present any new vocabulary before the function drama. After the function drama is finished, pass some clip on debriefing. This does non intend indicating out and rectifying errors. It is the procedure of debriefing which helps do the acquisition points. After the function drama, the pupils are satisfied with themselves ; they feel that they have used their cognition of the linguistic communication for something utile. This feeling of satisfaction will vanish if every error is analyzed. It might besides do the pupils less confident and less willing to make the other function dramas. Ask your pupils sentiment about the role-play, e.g. : What did you believe of the manner you handled X? How did it compare with the manner you deal with this in existent life? The purpose is to discourse what has happened in the function and what they have learned. Finally, do non bury to thank and praise the participants for their attempts. Example of function drama: We can play the picture where the characters are making something. The pupils watch it and so can reiterate some duologues. Then the instructor divides pupils into groups and they play the characters from the film dawdler, but extend the duologues harmonizing to their ain phantasy. After rectification and treatment they play the same scene once more. Simulation is defined as a world of map in a fake and structured environment. A simulation has three features: A world of map which means the participants in a simulation must step inside the function they have accepted and act consequently. A fake environment where there is no contact with the existent universe. A structured environment where the participants have all the facts and information provided for them.[ 6 ] Simulations have been used in many countries of preparation and instruction, such as the ground forces or in concern surveies. But in whatever country, linguistic communication is the tool used for communicating and Jones claim that simulation and linguistic communication are â€Å" virtually inseparable † . Simulation in ELT motivates scholars because simulation activities give them a opportunity to be involved in linguistic communication usage. It allows everyone to take part and even when errors are made, the instructor does non interfere. It gives chance for meaningful pattern of linguistic communication because most simulations involve interaction, either verbal or non-verbal, in spoken or written signifier. Well – planned simulations that are relevant to the scholars will surely promote earners to desire to finish the undertakings. The realistic ambiance in simulation is achieved through the careful readying of the stimulus stuff. Students take functions where the y behave as people in a wider assortment state of affairss which are close to existent life. Simulation encourages creativeness although it begins with information given to scholars. They need to be clever to bring forth the thought and to finish the simulation. Example of simulation: Title: To do a command 5 participants ( each pupil is given a function card with some information about a function and with counsel what to make: Finance Manager, Factory Manager, Gross saless Manager, Office Manager, and Director ) Situation: The company is doing available RM 10A 000 for upgrading merely one of the four sections. Each section is under the leading of a director ( as in the above ) . Each section is allowed to do a command for the amount of money saying the ground the money is needed. The Director will so make up one's mind the successful bidder. Language maps: Explaining, justifying, supporting, opposing. Time: 1 hr lesson Students are divided in groups of 5. At the terminal of the lesson, the Director studies on the determination for each group.GamesNot merely do many grownups enjoy games, but linguistic communication games really accelerate larning in a figure of ways. It is perfectly critical that big pupils know why they are utilizing a peculiar game, what specific mark grammar or vocabulary are they rehearsing, or what accomplishment are they reenforcing by utilizing the game. If pupils know and understand why they are making a peculiar activity they will be much more inclined to collaborate and bask the acquisition. Learning through merriment activities relaxes pupils and makes the schoolroom atmosphere much more supportive for scholars. Using adequate assortment in the type of activity or game will convey all four acquisition manners into drama: auditory, ocular and kinesthetic. Using games allows your pupils to acquire the most out of lesson clip, by passing it talking English. There are some links where you can happen a batch of games for grownup English scholars: www.teachingenglishgames.com www.ELTgames.com The of import advantage of all above mentioned activities is that they are wholly active methods of larning. Another benefit is that their existent value is frequently in the societal accomplishments they teach.6.3. Undertaking Workâ€Å" State me and I forget. Show me and I remember. Involve me and I understand † ( Chinese adage ) Undertaking work is a agency of communicating and enjoyment based on the combination of theory and pattern. A undertaking is an drawn-out piece of work on a peculiar subject where the content and the presentation are determined chiefly by the scholars. Students work in groups to work out disputing jobs that are reliable and frequently interdisciplinary. Learners decide how to near a job and what activities to prosecute. It can be used at every degree from absolute novice to progress. There can be involved all scholars mixed in ability, assurance and experience. The undertakings are really originative. The writers of the undertakings gather information from a assortment of beginnings and synthesise, analyze, and derive cognition from it and so set all the parts together to organize a consistent presentation. It is based on studentsA? demands and involvements. The instructor ‘s function is to steer and rede, instead than to direct and pull off pupil work. How to get down? Teach your pupils how to make undertaking work. Get down with concrete, small-scale activities. Decide the presentation signifier and the standards for its rating. Undertakings need to be seen or read so be after the last undertaking session as a presentation. Types of undertakings: Production undertaking Performance undertaking Collection undertakings Informational undertakings Orientation undertakings Social public assistance undertakings. Each undertaking needs to be evaluated. You can utilize a simple undertaking rating study, which remarks on facets of the undertaking such as content, design, linguistic communication work and besides evaluates the unwritten presentation phase of the undertaking. It can be discussed with all pupils from the category or group. Advantages of undertaking work are: It increases motive because all scholars are personally involved All four accomplishments – reading, composing, listening and talking are integrated Learning outcome – pupils have an concluding merchandise Undertaking is an reliable undertaking and therefore the linguistic communication input is more reliable There are developed interpersonal dealingss through working in a group It is learner centred – contend and methodological analysis can be decided between the scholars and the instructor A interruption from everyday.[ 7 ]6.4. DiscussionDiscussion is the prototypic learning method for active acquisition because it encourages pupils to detect solutions and develop critical thought abilities. . Discussion allows scholars to be active and experience personal contact. During treatment all participants speak to each other, explore, exchange positions, and larn from each other, pupils from instructor, instructor from pupils. Discussion is a state of affairs where pupils and instructor can and make do an unfastened, equal and personal response to a book, current societal job, manner, movies, political relations etc. which needs reading to take it beyond a factual statement. In a good treatment most members of the group experience willing able to talk when appropriate. Even in group where everybody contributes, there will be people who talk more than others. Dominant members of groups are frequently able and energetic people, whose enterprise can be used for other group membe rs, either in the thoughts they contribute to general treatment, or in some particular assignments, excess research or short talks they can set about. Silent member or people who speak seldom in a treatment can be soundless as a manner of demoing disapproval of what the remainder of group are stating or they can be diffident, diffident or lazy or because they prefer to listen to other people instead than to speak themselves. Problems of over-dominant and excessively soundless pupils can be solved by dividing the group into smaller groups for some portion of the category clip. Peoples who ne'er speak in the big group can state a batch in the smaller 1. Before treatment you can promote your pupil to fix for it. They can believe about a subject, read some stuffs and write notes and remarks. It is normal that for the first twosome of proceedingss the treatment is slow and hard to pull off, but if your pupils are prepared for it and you create a friendly atmosphere it can shortly warm up. If your purpose is a treatment which involves everyone, it is of import to run chairs in a circle, as that is the lone manner people can see or turn to each other easy than in sitting lecture- manner in consecutive lines.[ 8 ]DecisionIn decision, learning grownups should be different from learning kids and striplings. As we said, instructors of grownups should utilize a different manner of learning which is based on the theory of andragogy which suggest that grownups expect learner – centred scenes where they can find their ain ends and form their acquisition harmonizing to their present life demands. The learning techniques should be chosen wi th respect to demands of all scholars. We should see what attack and methods seem to be appropriate for our pupils. We have to esteem our pupils different larning manners, we should promote them, actuate them and give them a proper feedback. When our pupils know that the instruction procedure benefits them pragmatically, they will execute better, and the benefits will be longer enduring. Good instructors of grownups take all of these factors into history. Beyond learning your topic, you have the chance to animate assurance and passion in another human being. This is your challenge as a instructor of grownups.